It is known that drug infusion into the pleural cavity leads to direct exposure of tumour cells lining the surface of the pleural cavity. Systemic absorption from the pleural cavity is lower when compared with absorption from the peritoneal cavity during intraperitoneal hyperthermic chemotherapy procedures .The hyperthermia itself has a toxic effect on malignant cells and modifies the toxicity of the chemotherapeutic agent . However, systemic concentrations remain below toxic levels due to the limited absorption of the drug from the cavity. By attempting to “sterilise” the microscopic residual disease