Although early research studied the

Although early research studied the response of tremorto HIFU targeting of the Vim, other targets are also underinvestigation for the treatment of disabling movement disorders.For example, the internal globus pallidus is a preferred targetwhen patients’ symptoms are dominated by dyskinesia anddystonia. Previous research has demonstrated that pallidotomyand pallidal DBS lead to marked improvements in the symptomsand motor dysfunctions of PD (60).The current evidence suggests that HIFU is a safe andeffective option for patients with disabling ET or PD who arenot candidates for DBS or are reluctant to undergo surgery.However, more studies are needed to address the nontremor motor symptoms of movement disorders. Additionally, questionsregarding durability, the safety of bilateral treatment, and noveltherapeutic targets for tremor are currently being investigated inclinical trials.