The preservation of insulin-mediatedsalt absorption in the kidney is suggestive of the presence of salt-sensitivehypertension in conditions associatedwith insulin resistance. If so, shallwe recommend that individuals withmetabolic syndrome, obesity, or type 2diabetes mellitus limit their salt intakeeven before the onset of hypertension?Naturally, the best approach to controlhypertension in states associated withinsulin resistance is to reverse thecause of resistance, that is, throughweight loss, the use of insulin-sensitizing agents, or an assuage of IRSdysregulation. Alternatively, the use ofdiuretics that specifically inhibit saltreabsorption in the proximal tubulemay look appealing in individuals withhypertension due to insulin resistance.A classic example of the latter would becarbonic anhydrase inhibitors, such asacetazolamide. This option is specifically appealing if it is combined withthiazide derivatives, such as hydrochlorothiazide, which has been shownto prevent the generation of metabolicacidosis from acetazolamide monotherapy while enhancing its diuretic potency.9 The best approach to treatingpatients with insulin resistance andhypertension requires long-term studiesaimed at addressing the risk factors(insulin resistance, hypertension, and soon) and optimizing clinical outcomes.