Theauthors speculated that the stability of Brilliance CRE may have been compromisedduring transport of the culture media from the UK to Pakistan. However, in challengeexperiments with pure cultures, a relatively low specificity of 71% was recorded for thismedium due to the growth of AmpC- and/or ESBL-producing isolates (146). In anotherstudy with Brilliance CRE with patient samples (n ? 77), the specificity of Brilliance CREwas lower than that of SuperCarba (86.6% versus 98.5%, respectively) (149). However,the sensitivity of Brilliance CRE was significantly better than that of chromID CARBA fordetection of OXA-48 as shown by a study in Belgium (162). The sensitivity of bothmedia was improved by preenrichment of rectal swabs in MacConkey broth (althoughthis was not statistically significant), whereas prolonged incubation of media for 48 hshowed no advantage.