可以通过细胞膜微环境与细胞信号转导、黏附和增殖分化等生理过程密切相关，

The cell membrane microenvironment can be closely related to cell signal transduction, adhesion, proliferation and differentiation and other physiological processes. Therefore, visual analysis of the interaction between cells and the microenvironment can help deepen our understanding and understanding of related physiological and pathological processes. The team used nucleic acids and artificial prosthetic groups as modules to build a modular ratio-based cell membrane sensor based on nucleic acids, which enabled live cell imaging analysis of endogenous SO2 derivatives and NO and other signaling molecules in the cell membrane microenvironment. The modular strategy developed by the team combines the advantages of nucleic acid molecules and small molecule probes, providing a universal method for constructing ratiometric cell membrane sensors, and also providing new tools for biomedical research and disease diagnosis.

可以通过细胞膜微环境与细胞信号转导、黏附和增殖分化等生理过程密切相关，因此可视化分析细胞与微环境之间的相互作用有助于加深我们对相关生理和病理过程的理解和认识。该团队以核酸和人工合成的辅基为模块，构建基于核酸的模块化比率型细胞膜传感器，实现了细胞膜微环境中内源性SO2衍生物和NO等信号分子的活细胞成像分析。该团队发展的模块化策略综合了核酸分子和小分子探针的优点，为构建比率型细胞膜传感器提供了一个通用的方法，同时也为生物医学研究和疾病诊断提供了新工具。

It can be concluded that the membrane microenvironment is closely related to the physiological processes of cell signal transduction, adhesion, proliferation and differentiation. Therefore, the visual analysis of the interaction between cells and microenvironment is helpful to deepen our understanding of the relevant physiological and pathological processes. The team took nucleic acid and synthetic cofactors as modules, built a modular ratio cell membrane sensor based on nucleic acid, and realized the living cell imaging analysis of endogenous SO2 derivatives and no and other signal molecules in the cell membrane microenvironment. The modular strategy developed by the team integrates the advantages of nucleic acid molecules and small molecule probes, provides a general method for constructing ratio cell membrane sensors, and also provides a new tool for biomedical research and disease diagnosis.