Milder abnormalities of glucose tol

Milder abnormalities of glucose toleranceare evenmore common and occur at earlierages than CFRD. Whether individualswith IGT should be treated with insulinreplacement has not currently been determined.Although screening for diabetesbefore the ageof 10 years can identifyrisk for progression to CFRD in those withabnormal glucose tolerance, no benefithas been established with respect toweight, height, BMI, or lung function.Continuous glucose monitoring or HOMAof b-cell function (90) may be more sensitivethan OGTT to detect risk for progressionto CFRD; however, evidencelinking these results to long-term outcomesis lacking, and these tests are notrecommended for screening (91).