制剂对溶出度的影响主要与处方（辅料、表面活性剂等）、工艺及药物相互作用

制剂对溶出度的影响主要与处方（辅料、表面活性剂等）、工艺及药物相互作用有关。虽然不同晶型的利福平片的溶出度可能略有不同，但不同崩解时间的利福平片由于处方和工艺的不同，溶出度有明显差异，说明制备工艺是影响利福平片溶出度的关键因素。现代分析技术有助于我们进一步了解制备因素对药物溶出行为的影响。为了更好地了解速释片崩解与溶出的关系，采用动态光学粒子成像和粒子数平衡模型对同一处方、不同粒径的两种速释片在溶出过程中的粒子数和粒径进行了研究和监测。测定了片剂的溶出度和崩解度。

制剂对溶出度的影响主要与处方（辅料、表面活性剂等）、工艺及药物相互作用有关。 虽然不同晶型的利福平片的溶出度可能略有不同，但不同崩解时间的利福平片由于处方和工艺的不同，溶出度有明显差异，说明制备工艺是影响利福平片溶出度的关键因素。 现代分析技术有助于我们进一步了解制备因素对药物溶出行为的影响。 为了更好地了解速释片崩解与溶出的关系，采用动态光学粒子成像和粒子数平衡模型对同一处方、不同粒径的两种速释片在溶出过程中的粒子数和粒径进行了研究和监测。 测定了片剂的溶出度和崩解度。

The influence of preparation on dissolution is mainly related to prescription (excipients, surfactants, etc.), process and drug interaction. Although the dissolution of rifampicin tablets with different crystal forms may be slightly different, the dissolution of rifampicin tablets with different disintegration time is obviously different due to the different prescription and process, which indicates that the preparation process is the key factor affecting the dissolution of rifampicin tablets. Modern analytical techniques help us to further understand the influence of preparation factors on drug dissolution behavior. In order to better understand the relationship between disintegration and dissolution of rapid release tablets, dynamic optical particle imaging and particle number balance model were used to study and monitor the particle number and size of two kinds of rapid release tablets with the same prescription and different particle size in the dissolution process. The dissolution and disintegration of the tablets were determined.<br>