Abstract: This paper systematically analyzes the biological laws of the growth and reproduction of harmful microorganisms in the archives, the types of microorganisms that cause serious harm to the archives, and the harm of harmful microorganisms to the physical and chemical properties of the archives. Scientific research and Discussion on the principle and method of file disinfection technology. According to the technology and equipment of efficient file disinfection in different situations, this paper expounds the problems that should be paid attention to and effective measures taken for file safety disinfection.<br>Key words: safety of disinfection technology for the protection of harmful microorganism archives<br>
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