Table 1 provides an overview of human and animal studies in which platinum tissue concentrations during theHIPEC procedure with oxaliplatin were measured. As a result of major differences in the procedure, it is hard to compare the individual studies. Factors that have been identified to have an impact on the platinum concentration in tumour tissue are hyperthermia, pressure, dose, perfusate concentration, type of carrier solution and pretreatment with 5-FU