simple -Secreted α-Klotho overexpression reduced the expression level of synaptic vesicle protein SNAP 25 and attenuated paired pulse facilitation of glutamatergic neurotransmission, but increased evoked excitatory transmission.simple -Secreted α-Klotho overexpression altered activity dependent synaptic potentiation, but not synaptic depression.simple -These results indicate that memory formation benefits from an augmented level of secreted α-Klotho but that some aspects of social behavior were altered.Introduction