Concept proposing AD-related SCD is an intermediate state between normalcognition and MCI that may predict the development ofobjective cognitive declineEpidemiology Epidemiological datum of SCD differ from different studiesbecause of lack of unified terminology, criteria, screeningtools and so onClinicalCharacteristicsMemory decline is a common clinical manifestation(excluding depression, anxiety and so on)NeuropsychologicalAssessmentMost neuropsychological scales are still only for researchFluid biomarkers CSF and peripheral blood are meaningful predictivebiomarkers for SCDNeuroimagingExaminationComprehensive application of neuroimaging technology(PET, fMRI, DTI, etc.) contribute to the diagnosis of SCD andbetter understanding the pathologyPrognosis of SCD Remission, stabilized and progressing to MCI or ADIntervention NPI can be effective intervention for SCDRelevance toTraumatic BrainInjury-inducedcognitive deficits1. Although TBI is a potential risk factor of AD and affectivedisorders, currently, it is not clear how TBI-related cognitivedeficits are associated with SCD and AD. 2. SCD is oftenobserved in patients with a history of TBI. 3. People with TBIand AD also share similar pathological alterations. 4. If arelationship between TBI (-related SCD) and dementia canbe established, better diagnosis and early preventionstrategy could be designed to prevent TBI-related SCDand dementia