7.2.3.2.2 Activation of a Safety Instrumented SystemA safety instrumented system is considered to have been activated when called upon to function by a valid signalregardless of whether or not the SIS responds. A single initiating event may result in multiple SIS activations (e.g.facility-wide power failure) with each SIS activation being counted separately. Inadvertent or intentional activationduring maintenance activities should not be counted as a Tier 3 PSE, but may be counted in Tier 4.SIS activation that is configured for equipment protection with no related LOPC protection should not be counted as aTier 3 PSE.7.2.3.2.3 Activation of Mechanical Shutdown SystemA mechanical shutdown system is considered to have been activated when called upon to function by a valid signal,regardless of whether or not the mechanical shutdown system responds. Inadvertent or intentional activation duringmaintenance activities should not be counted as a Tier 3 PSE, but may be counted in Tier 4.PROCESS SAFETY PERFORMANCE INDICATORS FOR THE REFINING AND PETROCHEMICAL INDUSTRIESMechanical shutdown system activation that is configured for equipment protection with no related LOPC protectionshould not be counted as a Tier 3 PSE.7.2.3.2.4 Activation of Pressure Relief Device (PRD) Not Counted as Tier 1 or Tier 2A PRD is considered to have been activated when the system pressure reaches the device set point whether or notthe PRD Derforms as desianed. A sinale initiatina event mav result in activation of multiole PRDs (e.a, facilitv-wide