As noted in reference (1), if an in

As noted in reference (1), if an integrity test is nondestructive to the product or package, samples that pass package integrity testing may be further used in the stability testing for that specific test period or interval. However, samples should not be tested for package integrity at one time point (e.g., 12 months), then stored for further stability testing at a later time point (e.g., 24 months). While not specifically noted in reference (1), it is logical to assume that test samples earmarked for integrity verification over the course of the stability study could be checked for integrity before placement on stability if a nondestructive leak test method is used. This would be akin to the common practice of visually inspecting test samples prior to placing them on stability. In this way, subsequent integrity failures can be attributed to stability storage, rather than to other causes