Due to my elevated cholesterol levels I was told to start taking statins since diet and exercise had little to no effect on my levels. Unfortunately I was getting severe muscle cramps in my legs whenever I took the medication. Finally , the cardiologist advised that I try taking high doses ( specifically 400 mg a day) of CoQ10 to help with my leg cramps. I tried this and could not believe it actually worked!! There is one issue though...you MUST take the CoQ10 at the same time as you take the statin. I started out taking the CoQ10 in the AM and was told to take the statin in the evening, NOT a good idea!! Apparently the CoQ10 is much more effective in controlling the statin induced muscle spasms when taken at the same time as the statin!