Due to the extensive use of antibiotics, its metabolic residues are difficult to degrade in the environment. The pollution of antibiotics seriously affects the ecological environment and human health. The adsorption of ciprofloxacin on graphene oxide modified by halloysite was studied. The infrared structure of the product was characterized to determine whether it was modified or not. The factors affecting the adsorption effect of ciprofloxacin, such as solution pH and adsorbent dosage, were optimized. Finally, the adsorption thermodynamic and kinetic models were fitted, and the most suitable model for the adsorption experiment was obtained. The results showed that: under the condition of strong acid and strong base, it was not conducive to the adsorption of ciprofloxacin; under the neutral condition, the adsorption effect was better, and the optimal pH was 6; the optimal dosage of modified graphene oxide was 20 mg; the adsorption equilibrium of modified graphene oxide for ciprofloxacin was reached after 240 min. The adsorption data of ciprofloxacin were fitted by thermodynamic model, and the results showed that the Freundlich thermodynamic model was the best one to analyze the adsorption process.<br>
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