Ion channels have always been a hot topic in life sciences and drug research and development, serving as a key "gateway" to cells. They affect many important life processes and are closely related to various human diseases.Among them, volume regulated anion channel (VRAC) is widely distributed in mammalian tissues and cells, and has various pathological and physiological functions such as regulating cell volume, proliferation, differentiation, and migration. In 2014, Science and Cell first discovered that the protein LRRC8A encoded by the lrrc8a gene is a key component of VRAC, providing an important foundation for further research.The research on the relationship between LRRC8A protein and immunity is still in the preliminary exploration stage.