The purpose of this paper is to study the design of atmospheric distillation column for n-pentane and n-hexane, and to provide a feasible design scheme for industrial production.<br> Firstly, the chemical properties, physical properties and thermodynamic characteristics of n-pentane and n-hexane are analyzed in detail, and the optimal operating conditions are determined. On this basis, the number of trays is calculated by combining empirical formula and NRTL model. At the same time, through consulting the literature, the optimized operating conditions were determined. The distillation column models with different structures are established in HYSYS software and simulated. Each model has been tested and adjusted many times, so that it can minimize energy consumption, material flow and improve separation efficiency. After many experiments and adjustments, we finally got a design scheme of atmospheric distillation column suitable for industrial production. After comparing the performance of each model, we found that it is the best choice to take A-type pinhole plate as the basic structure, cooperate with special filler and add four increased hole positions as cutting points. The design scheme has good stability, can achieve the separation effect of high precision and small material flow, and can meet the actual production needs. To sum up, a design scheme suitable for industrial production is obtained through detailed research and optimization of atmospheric distillation columns for n-pentane and n-hexane. This research has certain guiding significance for optimizing the design of similar systems, and also provides valuable reference for related research in this field.<br> <br> Key words: distillation column model, thermodynamic characteristics, pinhole plate and cutting point
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