There are two plausible reaction pa

有两种可能的反应途径。一种是<br>氧鎓中间体直接与间苯二酚反应，<br>另一种是通过将<br>环状缩醛与溶剂醇进行缩醛化<br>反应而形成的无环双缩醛与间苯二酚反应（方案2）。为了确定<br>大环化反应的主要途径，使1,1,10,10-四烷基丙氧基癸烷在正丙醇<br>而不是4c中进行反应，这导致<br>1c的收率从97％显着降低至61 ％ 屈服。因此，<br>环缩醛的氧离子最有可能与间苯二酚反应，而反缩醛化<br>过程可以忽略不计。环状缩醛是<br>通常在酸性<br>醇中与其开放的氧鎓离子处于平衡状态。在高温下，平衡被推向<br>熵有利的开放形式，这可以<br>加速大环化反应。因此，<br>大环化需要高温以获得<br>双间苯二碳杂芳烃。

有两种合理的反应途径：一个是，一个<br>氧化物中间直接反应与撤销，和<br>另一个是，一个循环的双头肌，通过形成<br>循环乙酰与溶剂酒精的转位，<br>反应与雷索西诺（计划2）。确定主<br>宏观循环反应的通路， 1， 1， 10， 10 - 四基罗西德坎受到 n 丙醇的反应<br>而不是4c，这导致了显著减少<br>收益率从97%到61%的1c。因此，氧化铝离子<br>循环乙酰最有可能的反应与雷索西诺，和<br>跨性别过程可能微不足道。循环性乙酰是<br>通常在平衡与它的开放氧化铝离子酸性<br>醇。在高温下，平衡被推<br>对内向青睐的开放形式，这可以<br>加快宏观循环反应。因此，<br>大循环需要高温才能获得<br>比斯雷索西纳雷内斯。

There are two plausible reaction pathways; one is that anoxonium intermediate directly reacts with resorcinol, and theother is that an acyclic bisacetal, formed through thetransacetalization of a cyclic acetal with the solvent alcohols,reacts with resorcinol (Scheme 2). To determine the mainpathway of the macrocyclization reactions, 1,1,10,10-tetrakispropyloxydecane was subjected to the reaction in n-propanolinstead of 4c, which resulted in a significant reduction in theyield of 1c from 97% to 61% yield. Therefore, the oxonium ionof the cyclic acetal most likely reacts with resorcinol, and thetransacetalization process might be negligible. A cyclic acetal iscommonly in equilibrium with its open oxonium ion in acidicalcohols. At high temperatures, the equilibrium is pushedtoward the entropically favored open form, which canaccelerate the macrocyclization reaction. Accordingly, themacrocyclization requires high temperatures to obtain thebisresorcinarenes.<br>