Abstract: Biodegradable polymers are promising materials for use in medical applications such asstents. Their properties are comparable to commercially available resistant metal and polymericstents, which have several major problems, such as stent migration and stent clogging due to microbialbiofilm. Consequently, conventional stents have to be removed operatively from the patient’s body,which presents a number of complications and can also endanger the patient’s life. Biodegradablestents disintegrate into basic substances that decompose in the human body, and no surgery isrequired. This review focuses on the specific use of stents in the human body, the problems ofmicrobial biofilm, and possibilities of preventing microbial growth by modifying polymers withantimicrobial agents.