Our findings demonstrated that the serum levels of Cys-C in CAD patients were significantly higher than those in the non-CA Dgroup. Previous studies have shown that enhanced Cys-C expression in CAD patients was due to increased inducible ischemia and regional myocardial ischemia, indicating that higher Cys-C concentrations reflect potentially damaging increased elastolysis activity.23,24 However, our results showed that there was no significant difference in serum Cys-C levels between the stable and ACS groups, which suggests that the relationship between elevated Cys-C levels and increased elastolysis activity needs to be further studied.