The UK Biobank cohort study collected deep genetic and phenotypic data for each of the approximately 500,000 participants from UK, aged between 40 and 69 years. Volunteers from 22 study assessment centers across the UK completed questionnaires about their environment, lifestyle and medical history, took extensive physical measurements and collected blood, urine and saliva samples. All participants gave informed consent to the study[30]. Genotyping, quality control and imputation have been performed and described in this study