In which, the antibiotic removals was notably impacted by flow type for tetracycline in summer, lomefloxacin and roxithromycin in winter, norfloxacin and ofloxacin in both seasons, by substrate for ofloxacin in summer and lomefloxacin in winter, by plant for norfloxacin and erythromycin in winter, ofloxacin and tetracycline in both seasons,