其中一些方法是通过两步来进行染色体基因组三维结构建模，即将Hi-C数据

Some of these methods are two-step modeling of the three-dimensional structure of the chromosome genome, that is, the interaction frequency (IF) between the pair of fragments in the Hi-C data is converted into the distance between the pair of fragments, and then the distance value is optimized and inferred The three-dimensional structure that best meets the distance. The method to realize the two-step process is called a model based on distance constraints

Some of these methods are three-dimensional structural modeling of chromosome genomes in two steps, transforming the frequency of interaction between fragment pairs (IF) in Hi-C data into the distance between fragment pairs, then optimizing the distance values and inferring the three-dimensional structure that best meets the distance. The approach to implementing the two-step process is called a model based on distance constraints

Some of these methods are to model the three-dimensional structure of chromosome genome in two steps, that is, the interaction frequency (if) between segments in Hi-C data is converted into the distance between segments, and then optimize the distance value, and infer the three-dimensional structure that can best meet the distance. The method to realize these two steps is called distance constraint model<br>