Our study is limited in a few impor

Our study is limited in a few important ways. First, studies were heterogeneous with regards to population characteristics, particularly with regard to age and health status, which limit the generalizability of our findings. Furthermore, it is possible that only populations under stress psychologically, physiologically, or with an inflammatory condition, will reveal changes in the immune markers measured in response to MBTs. Second, interventions were heterogeneous with regard to type, frequency, and duration. Moreover, the mind-body therapies may not havebeen administered at a sufficient dose or for sufficient duration to affect immune changes. In addition, we are unable to make any determination as to whether immunological outcomes resulted from a single component of the multi-dimensional intervention or rather from the intervention as a whole. Third, the outcome itselfmay not be sensitive to change with MBTs. For example, CRP is an acute phase protein that is induced by IL-6, and increases of CRP occur only following robust activation of IL-6.