decompensated cirrhosis describes a

decompensated cirrhosis describes a more severe phase of disease during which the function of the liver is severely impairedand patients experience overt complications that may include:jaundice, ascites, hepatic encephalopathy and variceal haemorrhage.10 Whilst primary outcome measures of efficacy in clinicaltrials are largely focussed on histological changes that serve assurrogates for hard clinical endpoints,11,12 these measures fail tocapture the impact of the disease from a patient perspective.There is an increased focus on the patient’s subjective perceptionof the impact of disease and its treatment on his or her daily life,including emotional, social and physical functioning and wellbeing—this is referred to as health-related quality of life(HRQoL).