Although keloids and hypertrophic scars are common benign hyperproliferative growths of dermalfibroblasts, the clinical problems including physical and psychological problems are significant and impairing, with few proven treatments. Intralesional triamcinolone acetonide (TAC) and combination of TAC with 5-fluorouracil(5-FU) are widely used to treat keloids and hypertrophic scars, but their efficacy and safety remain controversial.Methods We systematically searched MEDLINE,EMBASE, Cochrane Library, and CNKI for relevant trials.Results The mean scar height and the erythema score in the TAC ? 5-FU group were lower than those in the TAC group after treatment (P .05). The effectiveness based on observer assessment after treatment in the TAC ? 5-FU group was superior than that in the TAC group (P 0.05)