In this paper, the design and implementation process of intelligent power supply system for commercial and residential quarters are described in detail with real-life building examples. According to the functional zoning, distribution of main electrical equipment and characteristics of each electrical equipment in the commercial and residential integrated residential area, the external power supply system, power transformation and distribution system, automatic short-circuit detection and disconnection system of electrical equipment, regional lightning protection system, and power supply guarantee system for civil air defense projects in emergency state are discussed in detail one by one.