摘要目的：探索小陷胸汤对2型糖尿病痰热互结症模型大鼠表征和血糖的影响。

摘要<br><br>目的：探索小陷胸汤对2型糖尿病痰热互结症模型大鼠表征和血糖的影响。方法：将46只大鼠适应性喂养一周后分为对照组（10只）和造模组（36只），对照组给予普通饲料喂养；造模组给予高脂高糖饲料喂养，在饲喂的第9周末确定造模成功后开始给药，将造模成功的大鼠分为小陷胸汤组（灌服小陷胸汤4周）、二甲双胍组（灌服二甲双胍4周）和模型组（模型组和对照组都灌服生理盐水4周）。除对照组外每组大鼠各12只，在第13周观察4组大鼠的各种表征变化情况以及第13周末进行一次口服葡萄糖耐量实验，检测4组大鼠给糖前0h血糖、0.5h血糖、1h血糖、2h血糖以及计算AUC值并进行分析比较。结果：（1）小陷胸汤组与模型组相比大鼠形体丰腴肥胖数减少、倦怠乏力减少、皮毛无光泽减少、凌乱成绺减少、目耳鼻唇舌颜色暗红数量减少正常淡红增多、二便坚硬和色黄减少、爪尾的污浊和暗红色也明显减少。小陷胸汤可明显改善大鼠表征，二甲双胍组同模型组相比虽也能小程度改善大鼠的表征但不如小陷胸汤组改善效果明显。（2）同对照组相比模型组、小陷胸汤组和二甲双胍组0h、0.5h、1h、2h血糖值均升高，同模型组相比小陷胸汤组大鼠0.5h血糖、1h血糖和2h血糖值均低于模型组，且糖耐量总曲线下面积与模型组相比也有明显降低。结论：小陷胸汤对2型糖尿病痰热互结症大鼠具有行气开郁、 疏肝理脾、燥湿化痰的作用，能够改善大鼠的中医临床症状；同时还能增强机体对糖的耐受能力、抑制机体对葡萄糖吸收的能力，改善糖代谢，可达到阻止疾病发展的作用。<br><br>关键词<br><br>小陷胸汤；痰热互结症；表征；2型糖尿病；糖耐量

摘要<br><br>目的：探索小陷胸汤对2型糖尿病痰热互结症模型大鼠表征和血糖的影响。 方法：将46只大鼠适应性喂养一周后分为对照组（10只）和造模组（36只），对照组给予普通饲料喂养；造模组给予高脂高糖饲料喂养，在饲喂的第9周末确定造模成功后开始给药，将造模成功的大鼠分为小陷胸汤组（灌服小陷胸汤4周）、 二甲双胍组（灌服二甲双胍4周）和模型组（模型组和对照组都灌服生理盐水4周）。 除对照组外每组大鼠各12只，在第13周观察4组大鼠的各种表征变化情况以及第13周末进行一次口服葡萄糖耐量实验，检测4组大鼠给糖前0h血糖、0.5h血糖、1h血糖、2h血糖以及计算AUC值并进行分析比较。 结果：（1）小陷胸汤组与模型组相比大鼠形体丰腴肥胖数减少、倦怠乏力减少、皮毛无光泽减少、凌乱成绺减少、目耳鼻唇舌颜色暗红数量减少正常淡红增多、二便坚硬和色黄减少、爪尾的污浊和暗红色也明显减少。 小陷胸汤可明显改善大鼠表征，二甲双胍组同模型组相比虽也能小程度改善大鼠的表征但不如小陷胸汤组改善效果明显。 （2）同对照组相比模型组、小陷胸汤组和二甲双胍组0h、0.5h、1h、2h血糖值均升高，同模型组相比小陷胸汤组大鼠0.5h血糖、1h血糖和2h血糖值均低于模型组，且糖耐量总曲线下面积与模型组相比也有明显降低。 结论：小陷胸汤对2型糖尿病痰热互结症大鼠具有行气开郁、 疏肝理脾、燥湿化痰的作用，能够改善大鼠的中医临床症状；同时还能增强机体对糖的耐受能力、抑制机体对葡萄糖吸收的能力，改善糖代谢，可达到阻止疾病发展的作用。<br><br>关键词<br><br>小陷胸汤；痰热互结症；表征；2型糖尿病；糖耐量

abstract<br>Objective: To explore the effect of Xiaoxianxiong Decoction on the expression and blood glucose of the model rats with type 2 diabetes mellitus. Methods: 46 rats were divided into control group (10 rats) and model group (36 rats) after one week of adaptive feeding, and the control group was fed with common feed; the model group was fed with high fat and high sugar feed, and the drug was given after the model was successfully established at the end of the 9th week of feeding. The rats were divided into Xiaoxianxiong Decoction group (4 weeks of Xiaoxianxiong Decoction), metformin group (4 weeks of metformin) Weeks) and the model group (both the model group and the control group were given saline for 4 weeks). In addition to the control group, 12 rats in each group were observed. At the 13th week, the changes of various representations of the four groups were observed and an oral glucose tolerance experiment was conducted at the end of the 13th week. The blood glucose of the four groups at 0 h, 0.5 h, 1 h, 2 h before the administration of glucose was detected and AUC value was calculated and compared. Results: (1) compared with the model group, the number of plump and fat rats in Xiaoxianxiong Decoction group decreased, the number of fatigue and fatigue decreased, the number of matted fur decreased, the number of disordered grain decreased, the number of dark red in eyes, ears, nose, lips and tongue decreased, the number of normal light red increased, the number of hard stool and yellow decreased, and the pollution and dark red in paw tail also decreased significantly. Xiaoxianxiong decoction can significantly improve the rat's characterization. Compared with the model group, metformin group can also slightly improve the rat's characterization, but it is not as effective as Xiaoxianxiong Decoction group. (2) Compared with the control group, the blood glucose values of 0 h, 0.5 h, 1 h and 2 h in the model group, Xiaoxianxiong Decoction group and metformin group were all increased. Compared with the model group, the blood glucose values of 0.5 h, 1 h and 2 h in the Xiaoxianxiong Decoction group were lower than those in the model group, and the area under the total glucose tolerance curve was also significantly lower than that in the model group. Conclusion: Xiaoxianxiong decoction can improve the clinical symptoms of TCM in rats with type 2 diabetes mellitus, improve the tolerance of glucose, inhibit the absorption of glucose, improve the metabolism of glucose, and prevent the development of the disease.<br>Key word<br>Xiaoxianxiong Decoction; phlegm heat syndrome; characterization; type 2 diabetes mellitus; glucose tolerance<br>