在配有磁力搅拌器、回流冷凝管的500ml单口圆底烧瓶中，依次加入ω-乙

In a 500ml single-necked round-bottom flask equipped with a magnetic stirrer and a reflux condenser, add 44.304g (0.213mol) of ω-acetoxymethyl camphene and 29.85g (0.533mol) of potassium hydroxide and dissolve it Distilled water, dropwise add to ω-acetoxymethyl camphene, then add 160ml of absolute ethanol, stir the reaction at room temperature (generally refers to 28-300C) for 18h, after the reaction is completed, transfer the reaction solution to a 1000ml beaker, add 200ml In ice water, and extracted with 3 * 25ml of petroleum ether, the organic phase was washed with distilled water until neutral, and the aqueous layer was separated. The oil layer was dried over anhydrous sodium sulfate, filtered, and transferred to a 150ml round bottom flask for rotary evaporation to remove petroleum ether , After refrigerated for several hours, a light yellow waxy solid can be obtained, and then the target product is recrystallized with petroleum ether. After drying, it can be weighed to obtain 25 g of white needle-like crystals (ie, ω-hydroxymethyl long leafene). The purity of the product by GC analysis was 99%, and the yield was 49.59%.

In a 500ml single-mouth round-bottom flask with a magnetic agitator and reflux condenser, add 44.304g (0.213mol), potassium hydroxide 29.85g (0.533) and make it just right Dissolved in distilled water, drip to omega-acetyloxymethylpenene, plus 160 ml of aqueous ethanol, at room temperature (generally referred to as 28-300C) stirring reaction 18h, after the reaction is completed to transfer the reaction liquid to 1000 ml of beaker, Add 200 ml of iced water, and extract with 3 x 25 ml of petroleum ether, organic phase washed with distilled water to neutral after the separation of water layer, oil layer with water-free sodium sulfate drying, filtration, transfer to 150 ml round bottom flask for rotary evaporation to remove oil Ether, after a few hours of refrigeration can be obtained pale yellow waxy solids, and then with petroleum ether to the target product recrystallization, after drying weighing can obtain white needle-shaped crystals (i.e. oxycodone long leaf ene) 25g, the product by GC analysis purity of 99%, The yield was 49.59%.

In a 500ml single port round bottom flask equipped with a magnetic stirrer and a reflux condenser, 44.304g (0.213mol) of ω - acetoxymethyl camphene and 29.85g (0.533mol) of potassium hydroxide are successively added and dissolved in distilled water, then ω - acetoxymethyl camphene is dripped and 160ml of anhydrous ethanol is added, and the reaction is stirred for 18h at room temperature (generally 28-300c). After the reaction, the reaction liquid is transferred to 1000ml of burning water In the cup, add 200ml of ice water, extract with 3 * 25ml of petroleum ether, wash the organic phase with distilled water to neutral, and then separate out the water layer, dry, filter and transfer the oil layer with anhydrous sodium sulfate to 150ml round bottom flask for rotary evaporation to remove petroleum ether, and obtain light yellow wax like solid after refrigerated for several hours, recrystallize the target product with petroleum ether, and weigh after drying The white acicular crystal (i.e. ω - hydroxymethyl Longifolene) 25g was obtained. The purity of the product was 99% and the yield was 49.59% by GC analysis.<br>