These differences can play an important role in the pharmacokinetics (PK) of oxaliplatin and thereby mightinfluence efficacy and/or safety of the HIPEC procedure.The present review provides an overview about the PK and pharmacodynamics (PD) of oxaliplatin during HIPEC procedures and the implications for clinical practice. It is surprising that a high-risk procedure as HIPEC, with a greatimpact on survival, has not yet been standardized.