It has been reported that TP promotes apoptosis of ovarian cancer cells by inducing tumor cells to produce a large amount of ROS. Compared with normal cells, the content of GSH in tumor cells is often very high, and drug-resistant tumor cells will react to synthesize GSH instantly when the GSH content decreases. This suggests that the increased GSH content may be related to tumor chemotherapy resistance. In addition, the increase in GSH content It also hinders the progress of ROS treatment of tumors. Therefore, we want to know whether nanoparticles co-carrying miR497 and TP can reduce GSH in OC cells and induce ROS production, thereby promoting the death of drug-resistant ovarian cancer cells. After SKOV3-CDDP cells were treated with PBS and miR497, we found that, as we expected, except for the control group, other groups could induce a large amount of ROS production and reduce the content of intracellular GSH. Among them, miR497/TP -HENPs have the most obvious effect.
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