This work reports a new type of microwave-induced catalytic oxidation material Co3O4, which was synthesized by a simple two-step method. Through the characterization and testing of the catalyst and the exploration of the degradation conditions of TC, it is proved that the nearly spherical Co3O4 prepared in the study has good microwave absorption properties, and the degradation of tetracycline hydrochloride under microwave induction is very excellent, which can achieve simple, rapid, and efficient removal of TC.