This is a first approach for understanding possible effects of deactivation during long-term applications of a microreactor in the PROX reaction that could be considered as a case study useful for future designs of this kind of devices. The presented information could be extrapolated to similar reactions where thermal treatments along with highly corrosive atmospheres would be applied, in order to carry out a more appropriate design of future generations of microreactors, with a longer useful life. For that purpose not only the adequate selection of the catalysts must be done, but also the adequate choice of the fabrication material of the reactors is needed.