Oxaliplatin is highly reactive in the blood and forms a variety of hydrolysed intermediates after intravenous infusion, including monochloro–dichloro- and diaquo-platinum species. Up to 17 platinum-containing derivatives have been observed in plasma ultrafiltrate (UF) samples frompatients. These intermediates rapidly react with endogenous low-molecular-weight molecules such as glutathione,cysteine and methionine, and high-molecular-weight compounds such as albumin, globulin and haemoglobin