The effect of the AMPK inhibitor CC on AMPK-induced Nrf-2 expression was tested. The results showed that inhibition of AMPK phosphorylation significantly inhibited AT-induced nuclear translocation of NRF-2, which in turn inhibited the expression of HO-1. Taken together, these results suggest that AT exerts antioxidant effects through the AMPK-Nrf-2 signaling axis.
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