Baseline Specimen Culture by Type o

Baseline Specimen Culture by Type of Gram-Negative Pathogen - All CasesType PathogenOther - Citrobacter amalonaticusOther - Citrobacter freundiiOther - K. oxytocaOther - serratia marcescensOther - Morganella morganiiOther - Stenotrophomonas maltophiliaA case of infection could have had more than 1 pathogen present in the baseline specimen culture.NA=not applicable; VABP=ventilator-associated bacterial pneumonia.Mechanism of Carbapenem ResistanceTable 4 presents a summary of the mechanism of carbapenem resistance for the CRE qualifying pathogen by infection type.Frequency distribution of MIC(μg/mL)by qualifying CRE pathogen for All Cases was summarized in Post-hoc Table 2.6.2.1 and by site of collection in Post-hoc Table 2.6.2.2.Summary of the Mechanism for Carbapenem Resistance for the CRE Qualifying Pathogen - All CasesKlebsiella pneumoniae - n(%)Metallo-carbapenemases[1]OXA carbapenemases[1]Other - Serratia marcescens - n(%)Enterobacter aerogenes - n(%)1.The denominator for each category was the number of pathogens for each infection type, for which the mechanism of carbapenem resistance was identified.AP=acute pyelonephritis; cUTI=complicated urinary tract infection; HABP=hospital-acquired bacterial pneumonia; KPC=Klebsiella pneumoniae carbapenemase;Antimicrobial SusceptibilityTable 5 presents a summary of antimicrobial non-susceptibility results by infection type(with≥10 isolates)for All Cases.Among all isolates across all infection types, 6 antibiotics were shown to have≥50% susceptibility against the isolates of CRE pathogens.The antibiotics with the highest incidence of susceptibility were polymyxin B(90.5%), colistin(73.2%), temocillin(63.6%), tigecycline(63.0%), gentamicin(56.9%), and minocycline(50.0%).Among all isolates tested against carbapenems, 97.4% tested non-susceptible to ertapenem, 96.7% tested non-susceptible to meropenem, 95.9% tested non-susceptible to imipenem, and 75.0% tested non-susceptible to doripenem.See Post-hoc Tables 2.6.4.1 and 2.6.4.2.See Post-text Data Listing 2.6.2 for a summary of MIC values and susceptibility results for All Cases.Summary of Antimicrobial Non-Susceptibility Results by Infection Type(with >10 Isolates)- All CasesAntibiotic Test% Non- Sus[3]Note:The dash symbol(-)represents isolates that were not tested by the corresponding antibiotic.Antibiotic tests are presented in descending order by percentage of non-susceptibility results in the All Cases column.N was defined as the number of isolates.% Non-susceptible equals% Resistant+% Intermediate(where either or both criteria are available), or 100% -% Susceptible(where neither Resistant nor Intermediate criteria are available).AP=acute pyelonephritis; CRE=carbapenem-resistant Enterobacteriaceae; cUTI=complicated urinary tract infection; HABP=hospital-acquired bacterial pneumonia; Non-sus=non-susceptible; Sus=susceptible; VABP=ventilator-associated bacterial pneumonia.Sources:Post-hoc Tables 2.6.4.1 and 2.6.4.2Sulfamethoxazole/trimethoprimTemocillinOf all 257 cases, 1 patient who did not have a qualifying index CRE was reported by the Investigator as having received both empiric and directed therapy.Of the 256 remaining cases, 201 patients were reported by the Investigator as having received both directed and empiric treatment, 27 patients were reported by the Investigator as having received directed treatment only, 15 patients were reported by the Investigator as having received empiric treatment only, and patients were reported by the Investigator as not having received any directed or empiric treatment.