IMPACT STATEMENTThis article evaluates in a structured way the performance of patient moving average quality control (MA QC) to support analytical quality control in a routine setting for both chemistry and hematological tests.The used MA QC procedures had a manageable number of alarms (< 1/day all together) and enabled (rapid) detection of critical error. This demonstrates that, when MA QC is properly optimized and implemented, MA QC enables the design of more efficient quality control plans. Especially the fast detection of critical error prevented the release of incorrect results and with that reduced the risk of clinical error.