option. In line with that, therefore, crystallized Tantalum oxide (Ta2O5) has been introduced85 as a potential choice due its characteristics supporting the prerequisite standards. Moreover,86 its superior role in resisting blood clot formation can rule out the chance of forming post-87 surgery deep vein thrombosis [9]. An in vivo study on Ta2O5 coated on SS 316 L88 demonstrated an excellent endothelial and human skin fibroblast attachment, proliferation and89 viability indicating its biocompatibility [9, 10]. However, a poor adhesion strength of the90 Ta2O5 on the substrate causing a premature failure of the implant coating. This limitation91 eventually has been overcome when Ta2O5 incorporated with Silver (Ag) [11]. Furthermore,92 the antimicrobial properties of Ag such as resistant to Escherichia coli (E. coli)93 and Staphylococcus aureus (S. aureus) become an added value for the Ta2O5 as a coating94 material [12]. However, a sustainable antimicrobial activity of Ag is determined by its size,95 dosage, agglomeration process, degradability level and exposure time to microbial cells. In96 several studies, a greater antimicrobial activity of Ag has been reported when it is in97 nanoscale particles [13, 14]. In fact, these Ag nanoparticles (AgNPs) have also shown a98 cytocompatibility against vast variety of cell types [9, 15, 16]. Nevertheless, an ideal method99 to achieve the best coating composite of AgNPs and Ta2O5 on the surgical instruments yet to100 be fully explored. Therefore a study was designed to characterise the Ag/AgTa2O5 Nano-101 composite film coated on SS 316L using Physical Vapor Deposition (PVD) magnetron102 sputtering technique for its physicochemical, antimicrobial and biocompatible properties. In103 addition, the correlations of deposition power and substrate temperature on these properties104 was further investigated.