It has been unveiled that 5-FU inje

It has been unveiled that 5-FU injected intralesionally once or twice weekly to hypertrophic scars and keloids is effective, with reduction of fibroblast activity in these scars [18, 35].Intralesional 5-FU injection is safe, with no systemic effects, when provided at a dose of 50 mg/mL [32]. But unwanted effects such as ulceration, erythema, and hyperpigmentation are common when pure 5-FU is used[36]. So to avoid adverse effects of a combination (TAChas been added to 5FU in a ratio of 1:9) used, a concentration equivalent to 4 mg/mL of TAC is not expected to have a role in efficacy, but this small amount of TAC most likely plays a different role by countering potential 5-FUinduced inflammation [7, 37]. Although some studies have also shown that TAC ? 5FU was better than TAC alone in treatment of these scars, too few randomised controlled trials (RCTs) testing these issues to be able to draw solid conclusions and the number of cases in these RCTs was small [18, 25, 38]. In this context, intralesional TAC ? 5FU has been postulated as an alternative strategy that can potentially reconcile the intralesional triamcinolone acetonide treatment dilemma by improving the scar while attenuating the rate of complications