The occurrence of tumor is the result of gradual accumulation of gene mutation. (1) The emergence of cancer cells generally requires 5 ~ 6 gene mutations. (2) The mutation of proto-oncogene will not form cancer immediately, but will continue to grow until there is a new gene mutation. (3) There are two copies of tumor suppressor genes, and only when they are lost or inactivated can cells become cancerous. However, if only one gene in two copies of proto-oncogene is mutated, it may become cancerous.
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