At present, the technology of ultrafiltration and nanofiltration can be used to extract spiramycin. The yield of spiramycin is 76.3%, which is much higher than that of traditional solvent extraction, and the product quality meets the requirements. In addition, ultrafiltration separation technology has been widely used in the production of cephalosporin, streptomycin sulfate, erythromycin, kalamycin sulfate and other antibiotics.