一般由数十个氨基酸组成[6]，根据与凝血酶结合方式的不同可将直接凝血酶

Generally composed of dozens of amino acids [6], according to the different ways of combining with thrombin, direct thrombin inhibitors can be divided into divalent direct inhibitors and monovalent inhibitors. The basic part of the binding, blocking the substrate recognition site of thrombin, followed by the N-terminal binding to the active center of thrombin, thereby inhibiting the catalytic activity of thrombin, such as hirudin and bivalirudin. The latter only binds to the active part of thrombin, such as argatroban, etc.

Generally composed of dozens of amino acids, according to the different binding methods with the clotting enzyme can be divided into two-price direct inhibitors and a valence inhibitors, the former is first of all c-end acid amino acids and the alkaline part of the clotting enzyme binding, closed clotting enzyme base identification site, followed by n end and clotting enzyme activity center binding, thereby inhibiting the catalytic activity of clotting enzymes, such as sulprentand and gluvan. The latter binds only to active sites of clotting enzymes, such as Agaquer, etc.

It is generally composed of dozens of amino acids [6]. According to the different binding modes with thrombin, direct thrombin inhibitors can be divided into bivalent direct inhibitors and bivalent inhibitors. The former is the combination of acid amino acids at the C-terminal and the basic part of thrombin, blocking the recognition site of thrombin substrate, and the second is the combination of N-terminal and the active center of thrombin, thus inhibiting thrombin For example, hirudin and bivalirudin. The latter only binds to the active part of thrombin, such as agatraban, etc<br>