The wet adhesion capability of SFB was evaluated bycomparison with two reported adhesives for surgeries andtissue engineering applications: PEU (poly(CA-Ser-co-Leuco-PPG)) and POEC-d (octanediol, PEO, citric acid, dopamine)[45]. For porcine skin, the wet adhesive strength of SFB(152.23±11.37 kPa) was approximately 14.4- and 4.5-foldgreater than those of PEU (10.6±2.1 kPa) and POEC-d(33.7 kPa), respectively. As a result, SFB exhibited betterwet adhesive strength than those of the reported adhesives.In summary, the adhesives formed using silk proteinfibroin/polyethylene glycol (SF:PEG) at the ratios of 16:4-18:2 possess the optimal mechanical properties. The suitablewater resistance obtained further supports the possibility ofusing silk protein fibroin bioadhisive in surgery.