Due to the potential toxicity of sulfite as widely used food additive, there is urgent need for the development oflow-cost, rapid and convenient sensors for sulfite detection. Toward this end, highly sensitive and selectivesulfite sensors based on solution gated graphene transistors (SGGTs) was innovatively developed. The performanceof the device was significantly improved through the functionalization of the gate electrode with multiwalledcarbon nanotubes (MWCNTs). We found that the MWCNT modified SGGT sensor showed an ultra-lowdetection limit of 30 nM toward sulfite. In addition, we also demonstrated that the SGGT-based sulfite sensor wascapable of detecting sulfite content in practical liquor samples with high recovery rate. Considering its low-costand easy-fabricating features, we believe that the SGGT-based sensor with appropriate functionalization may beapplied as a highly potential platform for ultra-sensitive detection of a broad range of important analytes inpractical samples for food safety purpose.