1. 基于免疫、造血功能的治疗机理和防护1） 近年来，肿瘤的免疫疗法及

1. Treatment and prevention mechanism based on immune, hematopoietic function <br>1) In recent years, a direction-tumor immune response and radiation therapy of tumor immunotherapy is lifted due to an unprecedented level. Unlike previous studies focus only study the killing effect of radiation on the tumor cell level, systematic active tumor immune response is thought to better reflect the advantages of radiation therapy, and the patient's prognosis is better. Therefore, to explore the cause of radiation treatment for cancer immune response and immune response mechanism is expected to provide strong support for the development of clinical cancer program of heavy ions; <br>2) since the Fukushima nuclear accident, more and more people for radiation protection seriously. Large doses of ionizing radiation can cause bone marrow pluripotent hematopoietic dysfunction, including erythroid, granulocyte, megakaryocyte and other blood cells is reduced, resulting in peripheral red blood cells, white blood cell and platelet levels were significantly reduced, increased organ bleeding, risk of infection and even death. Long-term low-dose ionizing radiation can damage the immune system, causing health disorders and other symptoms. Therefore, actively carry out biological effects of radiation protection policy based on laboratory research to improve the immune and hematopoietic function, to explore potential new target for Protection against Ionizing Radiation and effective protectants.

1. Treatment mechanism and protection based on immune and hematopoietic function<br>1) In recent years, the direction of the immune response of tumors caused by immunotherapy and radiation therapy has been raised to an unprecedented level. Unlike previous studies that focused solely on the killer effects of radiation on tumor cell levels, systematic active tumor immune responses are considered to better reflect the benefits of radiation therapy and better prognosis for patients. Therefore, to explore the way in which radiation therapy causes the tumor immune response and the mechanism of the immune response is expected to provide strong support for the formulation of clinical cancer treatment programs for heavy ions.<br>2) Since the Fukushima nuclear disaster in Japan, people have paid more and more attention to radiation protection. High-dose ionizing radiation can cause bone marrow multi-line hematopoietic dysfunction, including red, granulated, macronuclear cell reduction, resulting in a significant reduction in peripheral blood cells, white blood cells and platelet levels, increasing the risk of organ bleeding, infection and even death. Long-term acceptance of small doses of ionizing radiation can damage the immune system and cause symptoms such as physical dysfunction. Therefore, the Bioradiation Effects Research Office actively carries out research on protective strategies based on improving immune and hematopoietic function, and explores potential new targets for ionizing radiation protection and effective protective agents.

1. Treatment mechanism and protection based on immune and hematopoietic function<br>1) In recent years, the direction of tumor immune response caused by immunotherapy and radiotherapy has been promoted to an unprecedented level. Different from the previous studies only focusing on the killing effect of radiation on tumor cells, systematic active tumor immune response is considered to better reflect the advantages of radiotherapy, and the prognosis of patients is better. Therefore, to explore the way and mechanism of tumor immune response induced by radiotherapy is expected to provide strong support for the development of clinical treatment plan of heavy ion cancer;<br>2) Since Fukushima nuclear accident, people pay more and more attention to radiation protection. Large dose of ionizing radiation can cause the hematopoietic dysfunction of bone marrow, including the reduction of hematopoietic cells such as erythroid, granulocyte and megakaryocyte, which can significantly reduce the levels of peripheral blood erythrocytes, leukocytes and platelets, and increase the risk of organ bleeding, infection and even death. Long term exposure to low doses of ionizing radiation can damage the immune system and cause physical disorders. Therefore, the biological radiation effect laboratory actively carried out the research on the protection strategy based on improving immune and hematopoietic functions, and explored potential new targets and effective protective agents for ionizing radiation protection.<br>