Shown in Fig. 24 are preclinical ex

Shown in Fig. 24 are preclinical examples of both vessel co-opting and angiogenic tumors. Lung metastases from mice with breast cancer cell (MDA-MB-231/LM2–4) vs. kidney cancer (RENCA). The former develops purely non-angiogenic vessel co-opting lung metastases, whereas the latter forms both angiogenic (shown here) and vessel coopting lung metastases. Staining for lung-specific epithelial and EC markers shows the architecture of blood vessels in lung tissue and metastases. In vessel co-opting lung metastases, alveolar cells surrounding capillaries are taken up by the expanding mass at the tumor border, but alveolar epithelial cells are gradually shed from vessels toward the tumor center while capillaries remain.