Fuel and oxidant must be adequately supplied to ensure normal electrochemical operation of the PEM fuel cell, or abnormal reaction will happen to degrade the components. In the load-up process, the reactant supply lags behind the current increase . Thus, faster load-up results in more severe gas starvation. Moreover, the distribution and supply of reactants in a fuel cell are inherently uneven, especially in fuel cells with a large active area. For example, there are inherent differences between different locations in a fuel cell stack [35,235], between the gas inlet and the outlet of a fuel cell , and even between the rib region and the channel region [34]. Differences may be magnified in the load-up process, thus causing various degrees of gas starvation. The air starvation and the fuel starvation accelerate fuel cell aging in disparate ways.