Light sheets can be subject to distortion as they encounter objects that have not been cleared, resulting in shadows or striping in the image plane. SlideBook uses the SLM to create a patterned light sheet that interrogates the specimen from 3 different angles to mitigate (and in some instances completely eliminate) these artifacts. The images below show a coronal section of a mouse brain before (left) and after (right) automatic reduction of shadowing/striping effects.