CRP is an extremely sensitive indic

CRP is an extremely sensitive indicator of acute phase response. At present, it is one of the most widely used laboratory indicators for the diagnosis of infection or inflammatory response. When the level of C- reactive protein increases significantly, it indicates that there are obvious infectious diseases or inflammatory reactions in neonates. C-reactive protein in children with neonatal sepsis is characterized by high negative predictive value and low sensitivity. Studies have shown that when hypersensitive C-reactive protein ≥ 13.5 mg / L, the specificity and sensitivity are 7% and 76% respectively. The utility model has the advantages of low price, simple operation and less blood collection. When combined with peripheral hemogram and procalcitonin, it can effectively improve the accuracy of diagnosis, and its dynamic observation can guide the use of clinical antibiotics.