Stability of Aspirin in Different Media Aspirin rapidly hydrolyzes in 的简体中文翻译

Stability of Aspirin in Different M

Stability of Aspirin in Different Media Aspirin rapidly hydrolyzes in various aqueous, organic, andbiological media. The purpose of this investigation was to study the decomposition of aspirin in the media that comes in contact with it duringanalysis in biological fluids for pharmacokinetic studies. These mediaincluded water, water-polyethylene glycol 400,water-methanol-aceticacid, phosphate buffer, freshly drawn blood and plasma from control ratsand rats deprived of water for 36 hr, and blood precipitated with acetonitrile. Studieswere also conducted to determine the decomposition asa functionof temperature and pH. Of the varioussolvent systems studied,aspirin was found most stable in water-polyethylene glycol (4:1, v/v),which provides an excellent medium for preparation of intravenousdosage forms. Phosphate buffer showed significant catalysis of aspirinhydrolysis. A more than fivefold increasein the hydrolysisof aspirin wasnoted when the temperature was raised to 37' from 22.5'. The hydrolysisof aspirin in rat blood was 13times faster than that in plasma, with anaverage half-life in blood of -13 min. This creates significant problemsin aspirin disposition kinetic studies. Mixingthe blood sample immediately after collection with twice the volume of acetonitrile and thencentrifuginggives a plasma-acetonitrile mixture in which no lysisof bloodcells is observed
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阿司匹林在不同培养基中的稳定性阿司匹林在<br>各种水性,有机和<br>生物培养基中迅速水解。这项研究的目的是研究在<br>用于药代动力学研究的生物流体分析过程中与之接触的培养基中阿司匹林的分解。这些介质<br>包括水,水-聚乙二醇400,水-甲醇-乙酸<br>,磷酸盐缓冲液,来自对照大鼠<br>和缺水大鼠的新鲜抽取的血液和血浆36小时,以及血液中有乙腈沉淀。还进行了研究以确定分解与<br>温度和pH的关系。在研究的各种溶剂体系中,<br>发现阿司匹林在水-聚乙二醇(4:1,v / v)中最稳定,<br>这为制备静脉内<br>剂型提供了极好的培养基。磷酸盐缓冲液显示出阿斯匹林<br>水解的显着催化作用。<br>当温度从22.5'升高到37'时,阿司匹林的水解增加了五倍以上。<br>大鼠血液中阿司匹林的水解速度比血浆中水解快13倍,<br>平均血液半衰期为-13分钟。这<br>在阿司匹林处置动力学研究中产生了重大问题。采集后立即将血样与两倍体积的乙腈混合,然后<br>离心,得到血浆-乙腈混合物,其中未<br>观察到血细胞裂解
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Stability of Aspirin in Different Media<br> Aspirin rapidly hydrolyzes in various aqueous, organic, and<br>biological media. The purpose of this investigation was to study the decomposition of aspirin in the media that comes in contact with it during<br>analysis in biological fluids for pharmacokinetic studies. These media<br>included water, water-polyethylene glycol 400,water-methanol-acetic<br>acid, phosphate buffer, freshly drawn blood and plasma from control rats<br>and rats deprived of water for 36 hr, and blood precipitated with acetonitrile. Studieswere also conducted to determine the decomposition as<br>a functionof temperature and pH. Of the varioussolvent systems studied,<br>aspirin was found most stable in water-polyethylene glycol (4:1, v/v),<br>which provides an excellent medium for preparation of intravenous<br>dosage forms. Phosphate buffer showed significant catalysis of aspirin<br>hydrolysis. A more than fivefold increasein the hydrolysisof aspirin was<br>noted when the temperature was raised to 37' from 22.5'. The hydrolysis<br>of aspirin in rat blood was 13times faster than that in plasma, with an<br>average half-life in blood of -13 min. This creates significant problems<br>in aspirin disposition kinetic studies. Mixingthe blood sample immediately after collection with twice the volume of acetonitrile and then<br>centrifuginggives a plasma-acetonitrile mixture in which no lysisof blood<br>cells is observed
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结果 (简体中文) 3:[复制]
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阿司匹林在不同介质中的稳定性<br>阿司匹林在各种水溶液、有机物和<br>生物媒介。本研究的目的是研究阿司匹林在与之接触的介质中的分解情况<br>用于药代动力学研究的生物液体分析。这些媒体<br>包括水、水聚乙二醇400、水-甲醇-乙酸<br>对照组大鼠的酸、磷酸盐缓冲液、新鲜血液和血浆<br>大鼠断水36小时,血液用乙腈沉淀。还进行了研究,以确定分解为<br>研究了不同溶剂体系的温度和pH值的函数,<br>阿司匹林在水-聚乙二醇(4:1,v/v)中最稳定,<br>为静脉注射的准备提供了良好的培养基<br>剂型。磷酸缓冲液对阿司匹林有明显的催化作用<br>水解。阿司匹林的水解酶增加了五倍多<br>当温度从22.5'升高到37'时注意到。水解作用<br>大鼠血液中阿司匹林的含量是血浆中阿司匹林的13倍<br>血液中的平均半衰期为-13分钟。这会造成严重的问题<br>阿司匹林处置动力学研究。采集后立即将血样与两倍体积的乙腈混合,然后<br>离心产生血浆乙腈混合物,其中不溶解血液<br>观察到细胞<br>
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